Prof. Dr. Hans-Werner Mewes
Institut für Bioinformatik
GSF, Neuherberg
topics
Introduction
Von der organischen Chemie zum makromolekularen Biomolekül
The secrets of bioinformatics
From chemistry to bioinformatics
What do we expect from bioinformatics?
The systematic genome based biology
News from the past: Bayes as a principle
Probablistics as a useful tool
Context determines the biological function
Methods in Genome Annotation to collect sequence related attributes
A Parts List Approach to Cell Biology
Paradigm: Description of biological function requires multiple attributes
Omeomics
Combinatorial Analysis I: Gene prediction and redundancy
Pitfalls while predicting eukaryotic genes
Example IV
Identify potential exons from closely related organisms
Identify potential exons
Dialign Fragments
Complete Model
Evolution as the ordering principle in bionformatics
Segmental Duplications in A. thaliana
Combinatorial Analysis II: Functional and other classification
Systematic exploration of genome information: PEDANT
The MIPS Yeast Functional Catalogue
The Yeast Genome
Distribution of ORFs in completely sequenced genomes
Combinatorial Analysis III: Topology and Function
Do SN-Cycles exist?
Lysine Biosynthesis
Dependence of the number of SN-cycles
Combinatorial Analysis III: Protein/protein interaction and functional classification
Protein/Protein interactions and functional networks
Clustering of protein interactions
Mapping interactions to functions
Functional Context of YNR053c
Combinatorial Analysis IV: Expression analysis and functional classification
start presentation
go back to speakers list